Should we put off performing a Frozen embryo transfer after a fresh stimulation cycle?
It has been traditionally thought that it is better to let a woman’s body “settle down” after a fresh embryo transfer, if she doesn’t conceive, before having a frozen embryo transfer.
The reasoning was that hormonal changes immediately after a fresh cycle might decrease the pregnancy rates with frozen embryo transfers.
In fact, there is very little published evidence to support, or refute, this view.
A recent, multi centre, multi national study, published recently in Fertility & Sterility Journal, looking at almost 1200 frozen cycles in over 1000 women has provided excellent information regarding this. This study looked at women having Antagonist protocol Fresh cycles (as most Ballarat IVF women do), and looked at the pregnancy rates for those who had a frozen embryo transfer performed from their very first period after a stimulation cycle, compared to those who waited more than this before having a frozen embryo transfer.
The pregnancy rates in each group was exactly the same, at 32.5%, suggesting strongly that there is no benefit to be gained from waiting before frozen embryo transfer is planned.
Obviously, there are a variety of reasons why a woman or couple may choose to delay having a frozen embryo transfer, but improving her chances of conceiving is no longer one of them.